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, Xiaopeng Cui College of Biotechnology, Jiangsu University of Science and Technology , Zhenjiang, Jiangsu 212000 , China Search for other works by this author on: Oxford Academic Yuxin Yang College of Animal Science and Technology, Northwest A&F University , Yangling, Shaanxi 712100 , China Search for other works by this author on: Oxford Academic Minjuan Zhang College of Animal Science and Technology, Northwest A&F University , Yangling, Shaanxi 712100 , China Search for other works by this author on: Oxford Academic Lijun Bao College of Animal Science and Technology, Northwest A&F University , Yangling, Shaanxi 712100 , China Search for other works by this author on: Oxford Academic Feng Jiao College of Animal Science and Technology, Northwest A&F University , Yangling, Shaanxi 712100 , China Search for other works by this author on: Oxford Academic Shuang Liu College of Animal Science and Technology, Northwest A&F University , Yangling, Shaanxi 712100 , China Search for other works by this author on: Oxford Academic Hexin Wang College of Animal Science and Technology, Northwest A&F University , Yangling, Shaanxi 712100 , China Search for other works by this author on: Oxford Academic Xinlan Wei College of Animal Science and Technology, Northwest A&F University , Yangling, Shaanxi 712100 , China Search for other works by this author on: Oxford Academic Wei Qian College of Animal Science and Technology, Northwest A&F University , Yangling, Shaanxi 712100 , China Search for other works by this author on: Oxford Academic Xiang Shi College of Animal Science and Technology, Northwest A&F University , Yangling, Shaanxi 712100 , China Search for other works by this author on: Oxford Academic
https://orcid.org/0000-0001-7238-7759 , Chao Su College of Animal Science and Technology, Northwest A&F University , Yangling, Shaanxi 712100 , China Search for other works by this author on: Oxford Academic Yonghua Qian College of Animal Science and Technology, Northwest A&F University , Yangling, Shaanxi 712100 , China Shenzhen Fengnong Holding Co., Ltd , Shenzhen, Guangdong 518000 , China Corresponding author: qyh@nwafu.edu.cn Search for other works by this author on: Oxford Academic
Journal of Animal Science, Volume 102, 2024, skae076, https://doi.org/10.1093/jas/skae076
Published:
22 June 2024
Article history
Received:
23 March 2023
Accepted:
21 June 2024
Published:
22 June 2024
Corrected and typeset:
25 June 2024
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Xiaopeng Cui, Yuxin Yang, Minjuan Zhang, Lijun Bao, Feng Jiao, Shuang Liu, Hexin Wang, Xinlan Wei, Wei Qian, Xiang Shi, Chao Su, Yonghua Qian, Mulberry leaves supplementation alters lipid metabolism and promotes fatty acid β oxidation in growing mutton sheep, Journal of Animal Science, Volume 102, 2024, skae076, https://doi.org/10.1093/jas/skae076
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Abstract
Mulberry leaves (MLs) are an unconventional feed with fiber and various active ingredients, and are acknowledged as likely to regulate lipid metabolism, while the molecular mechanism remains undefined. Therefore, our objective was to define the role of MLs on the overall lipid metabolism. We conducted a feeding experiment of three groups on growing mutton sheep fed with dried mulberry leaves (DMLs), with fermented mulberry leaves (FMLs), or without MLs (as control). Analyses of transcriptome and widely target lipids demonstrated the addition of MLs triggered big perturbations in genes and metabolites related to glycerolipid, phospholipid, ether lipid, and sphingolipid metabolism. Additionally, the variations of the above lipids in the treatment of MLs possibly facilitate immunity enhancement of growing mutton sheep via the activation of complement and coagulation cascades. Furthermore, treatments with MLs could expedite proceedings of lipid degradation and fatty acid β oxidation in mitochondria, thereby to achieve the effect of lipid reduction. Besides, added DMLs also fuel fatty acid β-oxidation in peroxisomes and own much stronger lipolysis than added FMLs, possibly attributed to high fiber content in DMLs. These findings establish the novel lipid-lowering role and immune protection of MLs, which lays the foundation for the medicinal application of MLs.
Lay Summary
Mulberry leaves (MLs) are rich in a wide variety of active ingredients and are also a kind of traditional Chinese medicine with the same origin as medicine and food. Previous studies have found that MLs may regulate lipid metabolism. But the exact mechanism remains unclear. Our study reveals that ML supplement not only alters lipid metabolism including glycerol phospholipid, ether lipid as well as sphingolipid metabolism, which may help to improve immunity but also promote fatty acid degradation as well as β oxidation to achieve the effect of fat reduction.
© The Author(s) 2024. Published by Oxford University Press on behalf of the American Society of Animal Science. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)
Issue Section:
Metabolism and Metabolomics
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