Cyclosporine A (csa) Reverses Hairloss? (2024)

Here's a patent about Rivertowns lotion which has cyclo on it.

https://www.google.com/patents/US20170042859

They also speak of fractional laser therapy.

Maybe this is their way of delivering bigger molecules like cylclosporine?

“fractional laser therapy” or “fractional laser treatment” refers to application of a laser beam that is divided into thousands of zones and is capable of reacting with both the epidermis and dermis. This treatment is sometimes referred to as fractional laser photothermolysis.

Here is also a list of possible vehicle substances, dont know if this might shed some light on how they are planning on delivering big molecules into the skin.

The composition of claim 1 further comprising one or more excipients selected from the group consisting of urea, polyoxyl 40 stearate, a carbomer, cetyl alcohol, glyceryl monostearate, mineral oil, ethanol, propylene glycol, polyglycol 300, citric acid, sodium phosphate dibasic, stearyl alcohol, isopropyl myristate, sodium hydroxide, petroleum jelly, xanthan gum, white petrolatum, sorbitol solution, cetearyl alcohol, ceteareth-20, simethicone, sodium benzoate, glyceryl monostearate, polyethylene glycol monostearate, sorbic acid, butylated hydroxytoluene and water.

The formulating of the immediate above preferred embodiment may include the following:

• • weigh out 100 g 40% urea cream comprising X-Viate™ 40% cream: 40 g urea (w/v), carbopol, cetyl alcohol, glyceryl monostearate, light mineral oil, propylene glycol, water, sodium hydroxide, white petrolatum and xanthum gum; or emollient cream #1: 40 g urea plus 60 g emollient cream #1 (polyoxyl 40 stearate (103.125 g/L), propylene glycols (62.2 ml/L), polyglycol 300 MW liquid (46.875 ml/L), citric acid-anhydrous (1.1 g/L), sodium phosphate dibasic (2.04 g/L), cetyl alcohol wax (93.75 g/L), stearyl alcohol wax (200 g/L), isopropyl myristate (218.75/L), dd H2O to 1 L; sodium benzoate (3.125 g/L)); add 5 g minoxidil powder and then add 120 mg cyclosporine A powder or 120 mg cyclosporine A dissolved in 2 ml propylene glycol; followed by adding 50 μl of a 1M solution RT175 (>120 ng/ml final); and then mixing the resultant composition and loading it into 20 ml syringes or into tubes for dispensing.

some more info on their test results

• Example 4
• 59-Year-Old Male with Androgenic Alopecia Treated Topically with RT175 and RT175/Minoxidil
• [0107]
  A 59-year-old white with androgenic alopecia was treated twice daily with 1 milliliter of a composition containing 120 nanograms/milliliter (“ng/mL”) of RT175 in 30% w/v ethanol, 50% w/v propylene glycol and 20% w/v water. The composition was applied directly to the bald skin on the crown of the head once in the morning after showering and once before going to bed. Baseline hair distribution is shown in FIG. 4(a).
• [0108]
  FIG. 4(b) shows an absence of hair growth 4 months after RT175 treatment. The subject went on treatment holiday for 1 month, before beginning treatment with 120 ng/mL of RT175 and 5% w/v minoxidil in 30% w/v ethanol, 50% w/v propylene glycol and 20% w/v water. FIG. 4(c) depicts the subjects scalp before initiation of the second round of treatment. FIG. 4(d) shows the failure of the combination of RT175 and minoxidil to induce new hair growth.
• Example 5
• 57-Year-Old Male with Androgenic Alopecia Treated Topically with RT175/Minoxidil/Cyclosporine A
• [0109]
  A 57-year-old male with androgenic alopecia was treated twice daily with 1 milliliter of a composition containing 120 ng/mL of RT175 (0.000012% w/v), 1.2 milligrams per milliliter (“mg/mL”) of cyclosporine A (0.12% w/v) and 5% w/v minoxidil in about 28% w/v ethanol, about 47% w/v propylene glycol, and about 19% w/v water. The composition was applied directly to the bald skin on the crown of the head once in the morning after showering and once before going to bed. The extent of hair loss is depicted in FIG. 5 in the panel at the upper left (baseline).
• [0110]
  FIG. 5 upper right panel shows an unexpected and extensive hair growth after 21 days. FIG. 5 middle left panel shows continued hair growth after 28 days. FIG. 5 middle right panel show continued hair growth after 35 days and lower left panel shows additional hair growth at 42 days. These results are surprising in light of and in stark contrast to the findings in Example 4 that RT175 alone or in combination with minoxidil did not induce new hair growth in a male suffering from androgenic alopecia.
• Example 6
• 57-Year-Old Male with Androgenic Alopecia and Achromotrichia Treated Topically with RT175/Minoxidil/Cyclosporine a Displays Regrowth of Pigmented Hair
• [0111]
  A 57-year-old male with androgenic alopecia and who had already gone through achromotrichia (natural loss of pigmentation in the hair follicle and hair shaft) was treated twice daily continuously for 20 weeks with 1 milliliter of a composition containing 120 ng/mL of RT175 (0.000012% w/v), 1.2 milligrams per milliliter (“mg/mL”) of cyclosporine A (0.12% w/v) and 5% w/v minoxidil in about 28% w/v ethanol, about 47% w/v propylene glycol, and about 19% w/v water. The composition was initially applied directly to the bald skin at the crown of the head once after showering in the morning and once before going to bed. The composition continued to be applied after robust hair growth. At 5 weeks, the subject began growing pigmented hair in the area of the head where hair loss had occurred. See FIG. 6a . The new pigmented hair of the subject was of a similar color as the subject's hair prior to the subject undergoing achromotrichia. The hair outside of the treated area did not develop pigment. By the 20th week of treatment, there was extensive growth of pigmented hair over the totality of the treated area. See FIG. 6b . This result demonstrates that the composition of the invention not only regrows hair in patients with androgenic alopecia but also regrows pigmented hair in patients with androgenic alopecia who have undergone achromotrichia due to aging.